QY球友会

QY球友会生物
QY球友会生物 | 时空组学研究整体解决方案
发布时间:2019-12-11 浏览次数:544781
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QY球友会生物园区

QY球友会生物协助客户发表文章数据

QY球友会生物荣获:“10X Genomics  中国单细胞及空间组学优选服务商”

10X 单细胞空间转录组优质服务商


科研技术服务平台多样       满足不同样本实验需求

单细胞组学研究解决方案、单细胞多组学 =

▲QY球友会生物(部分)技术平台展示


序号 提供服务 技术平台 应用方向 服务样本保障
单细胞核 RNA 测序
【科研服务】
10X Genomics ★冰冻组织。
★FFPE 样本。
  • 应用方向同 单细胞 RNA 测序;
  • 核测序无法获得胞浆基因表达。
伯优®
QY球友会生物独研
细胞核分离试剂盒
单细胞 RNA 测序
【科研服务】

1、高通量平台:
10X Genomics;
BD Rhapsody;
2、低通量平台:
SMART-seq 2。
★肿瘤异质;
★肿瘤免疫微环境;
★胚胎发育;
★细胞分化。
(受细胞活率,悬液单胞率等影响)。
  伯优®
QY球友会生物独研
单细胞样本保存液
无惧异地时效影响
单细胞 ATAC 测序
【科研服务】

10X Genomics
★肿瘤异质性;
★免疫微环境;
★神经科学;
★胚胎发育;
★细胞分化等领域的研究。
单细胞 TCR/BCR 测序
(单细胞免疫组库测序)
【科研服务】

10X Genomics
BD Rhapsody
10X genomics 提供了全面的单细胞免疫分析方案;
通过精简的工作流程,可以实现从样品到文库准备、
免疫测序和软件分析全套解决方案,
揭示 T 和 B 细胞多样性、
V(D)J 重组和免疫细胞分析。
单细胞 ATAC+RNA 测序
(单细胞多组学联合)
【科研服务】

10X Genomics
★干细胞;
★免疫;
★癌症;
★神经科学。
伯优®
QY球友会生物独研
单细胞样本保存液
无惧异地时效影响
单细胞全长转录本测序
【科研服务】

Nanopore 
★发现不同细胞携带的突变,携带突变的细胞与非突变
细胞相比,挖掘基因表达规律。

★挖掘基因功能(如膜蛋白、分泌蛋白、转录因子等
编码基因转录本使用情况,并发现全新功能的转录本)。

★发现融合基因所在的细胞亚群,研究它们与肿瘤细胞
的拟时序分化关系。

★发现亚群特异性的全新 lncRNA。

★获得亚群特异性表达的转录本,能够辅助小核酸类药
物开发企业等。
伯优®
QY球友会生物独研
单细胞样本保存液
无惧异地时效影响
空间转录组测序
【科研服务】

10X Genomics Visium
★空间位置信息,或者细胞在组织中天然的状态。
★肿瘤学;
★免疫学;
★发育生物学;
★神经科学;
★病理学等方向。
伯优®
QY球友会生物独研
单细胞样本保存液
无惧异地时效影响
FFPE 空间转录组测序
【科研服务】

10X Genomics Visium
★空间位置信息,或者细胞在组织中天然的状态。
★肿瘤学;
★免疫学;
★发育生物学;
★神经科学;
★病理学等方向。
-


科研服务仪器平台任选

QY球友会生物
10X Genomics 仪器平台
39 25
仪器平台名称 Chromium Controller Chromium X
原理 Next GEM Next GEM
单次运行样本数 8 16
捕获细胞数 500-10,000 2,000-20,000
捕获效率 65% 65%
双细胞率 0.8% per 1000 cells 0.4% per 1000 cells
兼容性 不兼容新试剂 兼容旧试剂

科研服务仪器平台任选

研究成果

序号 协助客户发表文章 杂志 IF 日期 样本类型
1 Characterization of Cancer Stem Cells 1 in Laryngea Squamous Cell Carcinoma by Single-cell RNA Sequencing Genomics, Proteomics & Bioinformatics 11.5 2024 Sep 6 人喉癌组织
2 Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma CELLULAR ONCOLOGY 4.9 2024 Aug 08 人细胞
3 RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma Cell Reports 7.5 2024 Jul 24 人肺癌骨转移
4
Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis
Journal of the European Academy of Dermatology and Venereology 9.2 2023 Nov 人皮肤
5 Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus CLINICAL IMMUNOLOGY 8.6 2024 Jun 29 人晕痣
6
Activation of CD14+ Monocytes via the IFN-γ Signaling Pathway Is Associated with Immune-Related Adverse Events in Hepatocellular Carcinoma Patients Receiving PD-1 Inhibition Combination Therapy
biomedicines 3.9 2024 May 21 人外周血
7 Distinct roles of TREM2 in central nervous system cancers and peripheral cancers Cancer Cell 50.3 2024 May 23 小鼠脑胶质瘤
8
Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification
J Extracell Vesicles 16 2024 Apr 大鼠肌腱
9 Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non-responders Clinical and Translational Medicine 10.6 2024 May 23 人 Ileocyte 粘膜组织样本
10 Dissecting microenvironment in cystadenomas and hepatic cysts based on single nucleus RNA-sequencing data COMPUTERS IN BIOLOGY AND MEDICINE 7.7 2024 May 03 人肝囊肿
11 Mapping cell diversity in human sporadic cerebral cavernous malformations GENE 3.5 2024 May 22 人石蜡样本
12 An advanced comprehensive muti-cell-type-specific model for predicting anti-PD-1 therapeutic effect in melanoma Theranostics 12.4 2024 Mar 03 人骨软组织
13 Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes Nature Communications 16.6 2024 Feb 06  小鼠脾细胞
14 Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation CELL BIOLOGY AND TOXICOLOGY 6.1 2024 Feb 06  人组织 / 血液
15
Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway
Theranostics 12.4 2024 Feb 17 小鼠肾组织
16 Radiotherapy-Induced Astrocyte Senescence Promotes anImmunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth Advanced Science 15.1 2024 Feb 11 小鼠大脑组织
17 Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma
Communications Biology 5.9 2024 Jan 08 喉癌组织
18
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics
Advanced Science 15.1 2023 Nov 22 人肺癌组织
19 Single-cell and spatial heterogeneity landscapes of mature epicardial cells Journal of Pharmaceutical Analysis 8.8 2023 Jul 22 小鼠心脏
20
FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium
DEVELOPMENTAL NEUROSCIENCE 13.116 2023 Mar 10 小鼠脑
21
Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an antiferroptotic target in osteoarthritis
EBioMedicine 5.736 2022 Sep 19 人软骨
22
Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration
Theranostics 8.579 2023 Jun 12 人软骨
23
Single-Cell Sequencing Informs That Mesenchymal Stem Cell Alleviates Renal Injury Through Regulating Kidney Regional Immunity in Lupus Nephritis
STEM CELLS AND DEVELOPMENT 4 2023 Aug 8 小鼠肾脏
24 The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity Cell Metabolism 29 2023 Aug 04 结直肠癌组织
25 Role and Therapeutic Potential for Targeting Fibroblast Growth Factor  10/FGFR1 in Relapsed Rheumatoid Arthritis Arthritis and Rheumatology 13.3 2023 Aug 16 人滑膜组织
26 A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia Nature Communications 16.6 2023 Aug 04 人食管下括约肌 & 血液
27 Single-cell RNA sequencingreveals the Muller subtypes andinner blood-retinal barrierregulatory network in earlydiabetic retinopathy Frontiers in Molecular Neuroscience 6.261 2022 Dec 01 人视网膜
28
Single-Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural-Like Progenitor Program Associated with the Efficacy of Radiotherapy
Advanced Science 15.1 2023 Jul 09 人宫颈肿瘤
29 Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing JOURNAL OF DERMATOLOGICAL SCIENCE 4.6 2023 Jun 20 人皮肤
30 SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches CELL RESEARCH 46.297 2023 May 04 小鼠腿骨
31 The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer’s disease Journal of Pharmaceutical Analysis 14.026 2023 May 15 小鼠海马
32 General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis iScience 6.107 2023 Apr 21 人大脑前额叶皮质组织
33
Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma
SCIENCE ADVANCES 14.957 2023 April 12  人颅咽管瘤
34
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non‑small cell lung cancer revealed by single‑cell RNA sequencing
Genome Medicine 15.266 2023 Mar 03 人血液 / 肺癌组织
35 Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy Journal of Hepatology  30.083 2023 Jan 25 人肝脏
36
Single-cell RNA sequencing combined with single-cell proteomics
identifies the metabolic adaptation of islet cell subpopulations
to high-fat diet in mice
Diabetologia 10.46 2023 Jan 小鼠胰腺
37 Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports 9.995 2023 Jan 18 小鼠细胞
38
Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by
modulating the tumor environment of breast cancer
Frontiers in Immunology 8.786 2022 Oct 30 小鼠乳腺(癌)组织
39 A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer Protein & Cell 15.328 2022 Oct 26 人小鼠血液
40
Single-cell dissection of remodeled inflammatory
ecosystem in primary and metastatic gallbladder
carcinoma
Cell Discovery 38.079 2022 Oct 05 人胆囊组织
41 Defining Specific Cell States of MPTP-Induced Parkinson’s Disease by Single-Nucleus RNA Sequencing INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 6.208 2022 Sep 15 小鼠脑
42
Single‐cell transcriptome atlas reveals protective
characteristics of COVID‐19 mRNA vaccine
Journal of Medical Virology 20.693 2022 Sep 19 人肺组织
43
Tumor-polarized GPX3+ AT2 lung epithelial cells promote
premetastatic niche formation
PNAS 12.779 2022 Jul  小鼠肺组织
44 Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction frontiers in immunology 8.786 2022 Jun 29 人外周血
45 Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice Journal Of Hazardous Materials 14.224 2022 Feb 11 小鼠脑组织
46
Patient-derived organoids for personalized gallbladder
cancer modelling and drug screening
Clinical and Translational Medicine 8.554 2022 Jan 人胆囊组织
47 Anatlas of dynamic peripheral blood mononuclear cell landscapes in human perioperativeanaesthesia/surgery Clinical and Translational Medicine 8.554 2022 Jan 人外周血
48 Single-nucleus transcriptomic atlas of spinal cord neuron in human Elife 6.4 2021 Sep 30 人脑组织
49
Single-cell RNA Sequencing Technology Revealed
the Pivotal Role of Fibroblast Heterogeneity in Ang
II-Induced Abdominal Aortic Aneurysms
DNA AND CELL BIOLOGY 3.55 2021 Nov 小鼠肾上腹主动脉
50 iNKT subsets differ in their developmental and functional requirements on Foxo1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 12.779 2021 Nov 16 小鼠骨髓
51 Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 12.779 2022 Oct 小鼠肝组织
52 Single-cell profiling of tumor-infiltrating TCF1/TCF7 + T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer ORAL ONCOLOGY 5.972 2021 May 25 人口腔组织
53 A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia Antiviral Res 10.103 2020 Aug 小鼠肝组织
54
In vivo simultaneous transcriptional activation of
multiple genes in the brain using CRISPR–dCas9-
activator transgenic mice
Nature Neuroscience 28.771 2018 Mar 小鼠脑组织
55 Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and transcriptional activities of ECs in CC Molecular Therapy-Nucleic Acids 10.183 2021 Apr 2 人宫颈癌组织
56 A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells Cancer Res  13.312 2021 Feb 22 人肝组织
57
Characterization of the heterogeneity of endothelial cells
in bleomycin‑induced lung fibrosis using single‑cell RNA sequencing
Angiogenesis 10.658 2021 May 小鼠肺组织
58 Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain Cell Research 46.297 2021 Mar 10 小鼠腓肠神经
59 Liver type 1 innate lymphoid cells develop locally via an interferon-g–dependent loop Science 63.714 2021 Mar 26 小鼠肝脏细胞
60 Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules 38.079 2020 人肺癌组织
61 Somatosensory neuron types identified by high-coverage single-cell RNA sequencing and functional heterogeneity 46.297 2015 小鼠背根神经节


为什么要选择QY球友会生物?

1、QY球友会生物按客户需求真实开展实验,不辜负每一位客户的倾心托付。

2、QY球友会生物已通过 ISO9001:2015 国际质量标准认证,实验项目服务有保障。

3、QY球友会生物实验团队项目经验丰富,从样本到数据,实验质量有保障。

4、至今,风雨兼程 15 载,QY球友会生物与科研工作者共同携手,累计发布 SCI 论文 2500 余篇。平均影响因子大于 7.2 分。

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